Symbol
Name
ID

Rac2
Rac family small GTPase 2
MGI:97846

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Decreased lymphocyte proliferation in response to anti-CD3

Decreased circulating IgG level

Decreased circulating total IgM

Partial absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccine

Pancytopenia

Macrocytic anemia

Neutropenia

Neutrophilia

B lymphocytopenia

Abnormally low T cell receptor excision circle level

T lymphocytopenia

Lymphopenia

Monocytopenia

Leukocytosis

Leukopenia

Abnormality of neutrophil physiology

Impaired oxidative burst

Reduction of neutrophil motility

Impaired neutrophil chemotaxis

Hepatosplenomegaly

Disease(s) Associated with RAC2

immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis

immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia

immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia

Mouse Phenotypes

abnormal granulocyte differentiation

impaired neutrophil chemotaxis

decreased T cell proliferation

impaired hematopoiesis

decreased neutrophil cell number

increased neutrophil cell number

abnormal neutrophil morphology

decreased B-1 B cell number

decreased B-1a cell number

increased B-1 B cell number

increased B-1b cell number

decreased B cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased alpha-beta T cell number

increased alpha-beta T cell number

decreased T cell number

decreased lymphocyte cell number

decreased leukocyte cell number

increased leukocyte cell number

abnormal neutrophil physiology

decreased IgE level

decreased IgG level

decreased IgM level

increased IgM level

impaired natural killer cell mediated cytotoxicity

abnormal cytotoxic T cell physiology

Availability

Mouse Genotype

Rac2^m1Btlr/Rac2^m1Btlr

Rac2^M2Btlr/Rac2^M2Btlr

Rac2^m3Btlr/Rac2^m3Btlr

Rac2^M4Btlr/Rac2^M4Btlr

Rac2^M5Btlr/Rac2^M5Btlr

Rac2^tm1Mddw/Rac2^tm1Mddw

Rac2^em1Shl/Rac2⁺

Rac2^m1Btlr/Rac2⁺

Rac2^M2Btlr/Rac2⁺

Rac2^m3Btlr/Rac2⁺

Rac2^M4Btlr/Rac2⁺

Rac2^M5Btlr/Rac2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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